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The two disorders in this category refer to either the abuse or dependence on a substance.  A substance can be anything that is ingested in order to produce a high, alter one's senses, or otherwise affect functioning.  The most common substance thought of in this category is alcohol although other drugs, such as cocaine, marijuana, heroin, ecstasy, special-K, and crack, are also included.  Probably the most abused substances, caffeine and nicotine, are also included although rarely thought of in this manner by the layman.